Prerequisite: have Quicklisp installed somehow. Add to LD_LIBRARY_PATH all the things listed in quicklisp-to-nix-overrides.nix for library propagatedBuildInputs (a lot of these are done via addNativeLibs). Current list is: openssl fuse libuv mariadb libfixposix libev sqlite Add the needed system names to quicklisp-to-nix-systems.txt and load quicklisp-to-nix/ql-to-nix.lisp and call (ql-to-nix "/path/to/nixpkgs/pkgs/development/lisp-modules/") which is often just (ql-to-nix ".") Add native libraries and whatever else is needed to overrides. The lispPackages set is supposed to be buildable in its entirety.